People often are overweight and to combat this condition look to medication to lose weight. In many instances, people go on diet restrictions which lead to changes in their food consumption making them feel hungry all the time. It is due to this reason that people often discontinue it before ityields the best results. It is in this case that chemical drugs which are appetite suppressants are used which controls the brain by making you feel less hungry. One such type of the drug is Fen-Phen which is a similar weight loss pill.
The weight loss drug Fen-Phen
Fen- Phen is the nickname given to the combinatorial drug fenfluramine and phentermine. Fenfluramine was introduced in the market as a weight loss drug in the year 1970, and it was moderately used until it was used in combination with phentermine. Fen refers to the fenfluramine or dexfenfluramine which was marketed by the Wyeth Pharmaceutical and is a potent serotonin inducer. Phentermine, on the other hand, is an appetite suppressant which leads to therelease of norepinephrine, dopamine and serotonin in the body. The combination of weight-loss drugs gave efficient in the weight loss. The discovery that it caused additional heart problem was a big drawback. It was also reported to cause death in a woman due to heart problems which had been brought to the limelight by the media. It is due to this case and other cases where the heart valve dysfunction was reported by doctors in echocardiograms that FDA recommended the removal of the drug from the market in 1997.
Uses of Fen–Phen
Phentermine the drug belongs to a class of amphetamine class of drug is found to cause aneffective loss in weight. In fact, it is still recommended by doctors to cause weight loss in obese people having a body mass index of 30 or above. The other part of the combination drug fenfluramine or dexfenfluramine is not quite harmful when taken alone. It was initially reported to cause 4 of 41 cases of pulmonary hypertension. The combination of the two can lead to heart problems in an individual that leads to changes in heart valves. This is a very drastic effect on the drug use. It is due to this reason that it has been taken off the prescription drug market in the United States.
What caused Fen-phento go off themarket?
The reviews for the use fen-phenwas quite good for a time followed by a rapid decline. The use of the combination for a month caused anadmirable decrease of weight loss in an individual. Certain reports linked the use of this drug set with abnormal cardiograms. Sincethese changes were asymptomatic, it went unregistered in most cases. 24 cases were reported by Mayo Clinic of these drug users to have heart issues. Since then, 66 other cases were reported which had a similar effect. It is due to this reason that FDA removed the drug from the market with legal actions being taken against the pharmaceutical firm with legal damages of over $13 billion for fenfluramine or dexfenfluramine. On the other hand phentermine, one of the drugs of the combination is still the third most popular drug for weight loss and obesity control and does not cause similar side effects. So it can be said that the combination of weight-loss drugs is not recommended for use, but phentermine can still lead to efficient weight loss.